SYNTHESIS OF 1-ALKYL-2-AMINO-IMIDAZOL-5-CARBOXYLIC ACID ESTER VIA CALPHA-SUBSTITUTED N-ALKYL-GLYCINE ESTER DERIVATIVES

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United States of America Patent

SERIAL NO

15028200

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Abstract

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The invention provides an efficient and high yielding process for preparing TH-302, comprising at least one step wherein a dioxolane intermediate is generated in an aqueous layer, resulting in a synthesis that is amenable to scale up conditions.

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Patent Owner(s)

Patent OwnerAddress
MERCK PATENT GMBHDARMSTADT

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
BREUNING, Marcel Andre Frankfurt am Main, DE 3 7
DEBOR, Michaela Stockstadt, DE 1 4
HAHN, Helmut Dieter Ruesselsheim, DE 1 4
JASPER, Christian Seligenstadt, DE 33 166
KRATTIGER, Philipp Darmstadt, DE 2 17

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