Prefusion RSV F proteins and their use

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United States of America Patent

PATENT NO 9738689
SERIAL NO

14207372

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Abstract

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Disclosed are immunogens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the immunogens and methods of producing the immunogens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the immunogen to the subject.

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Patent Owner(s)

Patent OwnerAddress
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICESOFFICE OF TECHNOLOGY TRANSFER NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE SUITE 700 MSC 7788 BETHESDA MD 20892-7788

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Man Bethesda, US 30 102
Graham, Barney Rockville, US 31 137
Joyce, Michael Gordon Washington, US 33 195
Kwong, Peter Washington, US 55 200
McLellan, Jason Norwich, US 24 161
Zhang, Baoshan Bethesda, US 35 163
Zhou, Tongqing Boyds, US 44 202

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