Asymmetric synthesis of pregabalin
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United States of America Patent
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May 10, 2005
Grant Date -
Nov 13, 2003
app pub date -
Jan 11, 2001
filing date -
Jan 27, 2000
priority date (Note) -
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Abstract
This invention provides a method of making (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid (pregabalin) or a salt thereof via an asymmetric hydrogenation synthesis. Pregabalin is useful for the treatment and prevention of seizure disorders, pain, and psychotic disorders. The invention also provides intermediates useful in the production of pregabalin.
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