Cardiac glycosides and their aglycone derivatives treat complications of diabetes
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United States of America Patent
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Aug 28, 2001
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N/A
app pub date -
Dec 17, 1999
filing date -
Feb 12, 1996
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Abstract
This invention provides methods of inhibiting the export of a leaderless protein from a cell by contacting the cell with a cardiac glycoside or aglycone derivative. Leaderless proteins include FGF-1, FGF-2, IL-1.alpha., IL-1.beta. and factor XIIIa. These methods are useful in treatment of conditions, including tumors and diabetes.
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