Synthesis and resolution of propionic acid derivatives
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United States of America Patent
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May 12, 1998
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N/A
app pub date -
Nov 5, 1996
filing date -
Nov 17, 1995
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Expired
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Abstract
A process for the production of disubstituted propionic acid derivatives which are intermediates in the synthesis of .alpha.-arylpropionic acids such as naproxen, involves the reaction of a naphthalene derivative such as 2-methoxynaphthalene, with an alkylating agent such as an alkyl pyruvate in the presence of a catalyst, and then dehydrating and hydrogenolising, or directly hydrogenolising, or derivatising and then hydrogenolising the product thereof, to produce the desired compound.
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